Suppression of genotoxicity of X-rays in somatic cells of Drosophila melanogaster by (-)-epigallocatechin gallate, (-)-epigallocatechin, and theaflavin digallate

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Larval Drosophila melanogaster heterozygous for the somatic cell marker mutation mwh were fed on medium containing green tea catechins (-)-epigallocatechin gallate (EGCg, (-)-epigallocatechin (EGO , or theaflavin digallate (Tdg) or on catechin-free medium and irradiated with X-rays ; after emergence as adult flies, the wings were inspected for mutant clones expressing the phenotype of the marker. The EGCg-, EGC-, and Tdg-treated groups all showed a clear reduction in the yields of X-ray-induced mutant clones compared with the untreated groups. Since the size distributions of mutant clones were not affected by the presence of the catechins, we conclude that EGCg, EGC, and Tdg have a radioprotective effect at the chromosomal level in somatic cells of D. melanogaster under the conditions applied.
1999-07-12