Genotoxic potency of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone in Drosophila melanogaster somatic cells in vivo

スポンサーリンク

概要

• 論文の詳細を見る

• 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone(MX), a mutagenic byproduct of chlorine disinfection, was assayed for DNA damaging potency and genotoxicity in vivo in Drosophila melanogaster using, respectively, the mei-9^a mei-41^<D5> DNA repair test and the mwh/flr^3 wing spot test. MX was inactive in both assay systems, despite the high mutagenicity of MX in Salmonella TA100 strain. Treatment of this Salmonella strain with MX in the presence of S9 fraction from larval flies plus cofactors greatly reduced MX mutagenicity, demonstrating the existence of an efficient MX detoxifying system in larval somatic tissues. These results propose a pharmacodynamic reason why the consumption of water containing parts per trillion levels of MX might not represent an unacceptable hazard to human health.

• 日本環境変異原学会の論文
• 1998-04-10

著者

• Kawai Kazuaki

  Faculty Of Engineering Toin University Of Yokohama

• Kawai Kazuaki

  Faculty Of Pharmaceutical Sciences Meijo University

関連論文

• Suppression of genotoxicity of X-rays in somatic cells of Drosophila melanogaster by (-)-epigallocatechin gallate, (-)-epigallocatechin, and theaflavin digallate
• Enhancement of the DNA Damaging Activity of N-Nitrosodimethylamine by Di-(2-ethylhexyl)phthalate in Somatic Cells in Vivo of Drosophila melanogaster
• Genotoxic potency of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone in Drosophila melanogaster somatic cells in vivo
• Apoptosis Induction in Cancer Cells by Ultrasound Exposure
• New curvularin-type metabolites from the hybrid strain ME 0005 derived from Penicillium citreo-viride B. IFO 4692 and 6200.

スポンサーリンク