ダイオキシンの継世代催奇性 : 第10回公開シンポジウム : 内分泌撹乱物質の作用機序と後世代影響 : 環境変異原研究との接点

概要

論文の詳細を見る
Epidemiological studies in USA on the reproductive outcomes of Vietnam veterans exposed to Agent Orange, a mixture of herbicide contaminated with 2,3,7,8-TCDD (dioxin) , have shown no clear evidence for an association between herbicidal exposure and the risk of fathering babies with congenital defects. Similarly, experimental evidence for male-mediated teratogenicity of dioxin is not clear at present. On the other hand, reliable negative data are available for dioxin clas-togenicity in human spermatozoa in vitro and the clastogenicity and DNA-damaging effect in germ cells of male mice. However, germ-cell degradation has been reported in male mice exposed to dioxin, and this has been verified to occur as a consequent of Sertoli cell injury. These results and other relevant data are reviewed and discussed. Finally, need for further accumulation of animal data is pointed out so that a final conclusion on the genetic hazard of dioxin can be achieved. (This paper, chaired by Kiyomi Kikukawa, was presented to the 10th JEMS Annual Symposium, "Endocrine Disruptor Mechanism and Posterity Effects-Concern with Environmental Mutagen Research", organized by Kiyomi Kikukawa, Tohru Shibuya, and Kazuo Fujikawa, sponsored by the Environmental Mutagen Society of Japan, and held at The Pharmaceutical Society of Japan, Nagai Memorial Hall, May 28, 1999.)
日本環境変異原学会の論文
1999-10-29