内分泌撹乱化学物質の精巣毒性と継世代催奇形成 : 第10回公開シンポジウム : 内分泌撹乱物質の作用機序と後世代影響 : 環境変異原研究との接点
スポンサーリンク
概要
- 論文の詳細を見る
Male mice prenatally treated with a synthetic hormone, estradiol benzoate (EB, 0.15 and 0.3mg/ kg/day) , were mated with untreated females, and resulting fetal offspring were inspected for external malformations. A significant increase in the incidence of malformed fetuses over the control level was noticed in the offspring whose sires were treated with a high EB dose, but it was not seen in the offspring of males treated with a low dose. The high dosing, but not the low dosing, caused partial atrophy and feminization in the genital tracts. Ethinyl estradiol also showed transgenerational teratogenicity when applied prenatally at a dose which caused histopathological changes in the testes. Germ-cell series in normal testis have mechanisms to select against spontane-ously arisen mutations ; but these selection mechanisms may not function efficiently in chemically damaged testis. Based on these results and considerations, I propose as a working hypothesis that male-mediated teratogenesis may occur as a consequence of testicular toxicity. (This paper, chaired by Kiyomi Kikukawa, was presented to the 10th JEMS Annual Symposium, "Endocrine Disruptor Mechanism and Posterity Effects-Concern with Environmental Mutagen Research", organized by Kiyomi Kikukawa, Tohru Shibuya, and Kazuo Fujikawa, sponsored by the Environmental Mutagen Society of Japan, and held at The Pharmaceutical Society of Japan, Nagai Memorial Hall, May 28, 1999.)
- 日本環境変異原学会の論文
- 1999-10-29
著者
関連論文
- Behavioral Characteristics of Rats Selectively Bred for High and Low Avoidance Shuttlebox Response
- Comparative Susceptibility of a Wild Derived Strain of Mus musculus molossinus and Laboratory Mice to Teratogenesis by Ethylnitrosourea
- P-108 Aminophenylnorharmanのマウス始原生殖細胞に対する細胞毒性
- Treatment of Mouse Preimplantation Embryos with Adriamycin, Methyl Methanesulfonate and Retinoic Acid Results in Congenital Defects
- Camitine and Coenzyme A Decrease Valproic Acid-Induced Neural Tube Defects in Mice
- N-methylnitrourea(MNU)およびmethylazoxymethanol (MAM)誘発小頭症ラットの行動・機能異常
- Dexamethasoneおよびdexamethasone-17, 21-dipropionateのラットにおける催奇形性
- 牛肉の抗疲労効果について
- Reproductive Effects of Early Neonatal Exposure to Diethylstilbestrol or Tamoxifen in Rats
- 内分泌攪乱物質とその周辺
- Male-Mediated Developmental Toxicity: Enhanced Susceptibility to Induced Teratogenesis in the Offspring of Male Mice Treated with Ethylnitrosourea
- 雄マウスの変異原処理によるF_1奇形と自然発生奇形
- Modified Susceptibility to Teratogenesis in the Offspring of Male Mice Exposed to Mutagens
- 5-Fluorouracil (5-FU) のラット培養胚への影響
- Exposure to Ethylnitrosourea Before Implantation Induces Congenital Malformations in Mouse Fetuses
- Frequency and Type of Malformations in the Offspring of C57BL/6 Male Mice Treated with Ethylnitrosourea
- 発生毒性と薬物相互作用
- Effects of Mitomycin C Treatment before Implantation on Development of Mouse Embryo
- Studies on the Relation between Alkylating Agent-Induced Chromosomal Aberrations and Embryotoxicity in Mice. II. The Potentiation of Teratogenicity and Clastogenicity of Isopropyl Methanesulfonate, N-Methyl-N-Nitrosourea and Dimethyl Sulfate by Caffeine
- N-methylnitrosoureaによって誘発されたラット小頭症個体の生後の行動異常
- 29. 雄マウスに投与されたmethyl methanesulfonateの胎児の発生に及ぼす影響
- 内分泌撹乱化学物質の精巣毒性と継世代催奇形成 : 第10回公開シンポジウム : 内分泌撹乱物質の作用機序と後世代影響 : 環境変異原研究との接点