院内製剤レバミピド注腸剤の安定性試験と有効を示した臨床例

概要

論文の詳細を見る
Rebamipide, an antiulcer drug, has been reported to possess an antioxidant effect and to restore the impairment of antioxidants in experimental colitis. Recently, a rebamipide rectal suspension enema has been investigated as one type of pharmacotherapy to treat ulcerative colitis (UC). This enema has been prepared in-house, but its stability has not yet been examined. In our hospital, we prescribe a drug for which its stability is unknown for only a short period. This enema could not be prescribed with other drugs that could be prescribed for a longer period. As a result, such patients have come to the hospital frequently, which makes the treatment regimen more difficult. We determined the contents of rebamipide contained in the enema using HPLC, and ob-served no significant changes after 5 weeks of storage, which thus made its longer-term prescription possible. We also experienced a patient with moderate rectal UC who encountered adverse effects related to steroid treatment. While tapering the dosage of steroids, we administered the rebamipide rectal suspension enema, and the patient responded well to the agent.
日本医療薬学会の論文
2003-06-10