点眼・点耳・点鼻薬に配合されている防腐剤のメチシリン耐性黄色ブドウ球菌に対する防腐効果について

概要

論文の詳細を見る
A comparative study on the antiseptic effects of external medicines for eyes, ears, and nose was conducted using clinically isolated methicillin-resistant staphylococcus aureus (MRSA) and staphylococcus aureus ATCC No.6538 (S.aureus), one of the index bacteria employed in antiseptic tests. The efficacies of these external medicines against MRSA and S.aureus mainly depend on the antiseptics compounded in them. The effects of medicines incorporating benzalkonium chloride (BAC) against MRSA were not significantly different from those against S.aureus; neither MRSA nor S.aureus grew much within 6 hours after inoculation. The results obtained 6 hours after the inoculation by the use of medicines with chlorobutanol (CB), those with than admixture of paraoxylbenzonates (AP) such as methylparaben (MP) and propylparaben (PP), those with a mixture of MP and CB, and those with a mixture of AP and CB were 58 to 71% for MRSA and 63 to 78% for S.aureus. The bacteria were completely eliminated 7 days later. Their efficacies against MRSA, however, were slightly weaker than those against S.aureus. The minimum inhibitory concentration values of eye drops were measured; the values of BAC against MRSA were slightly higher than those of S.aureus. No significant differences, however, were observed between the AP and CB values.
日本医療薬学会の論文
1993-08-20