インフルエンザワクチン接種後の副反応調査2003-2004シーズン

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It has been pointed out that adverse effects due to influenza vaccine recorded in clinical on-site reports differ from those mentioned in package inserts. While there have been many studies on the effects of vaccines to date, there have been few detailed studies on adverse effects. Their clinical symptoms resemble those of SARS. Also, while rare serious adverse effects have been a source of concern, slight or moderate adverse effects have drawn little attention. Against this background, we conducted an investigation of adverse effects following the inoculation of our hospital staff (361 males, 908 females) with influenza vaccine. The occurrence rate of local reactions was 45.1% and that of systemic reactions 20.8%, which were higher than the rates stated in the package inserts. Also, on checking the results of the previous year's vaccination, we found that rates had increased. While the occurrence rate was significantly higher in females than in males, the rate in elderly subjects of 60 or older was significantly lower than that in younger subjects. We also determined the impact of various independent factors using a multiple logistics model. In conclusion, actual occurrence rates for adverse effects do not necessarily agree with those stated in package inserts, which may be because rates are affected by vaccination history and various other factors. Our findings will aid the prediction and management of adverse effects.
日本医療薬学会の論文
2005-04-10

インフルエンザワクチン接種後の副反応調査2003-2004シーズン

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