摂食行動・性行動の神経生理(心身医学の基礎研究)(第31回日本心身医学会総会)

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The hypothalamus plays important role in neuro-humoral control of food intake, sexual behavior and relevant visceral functions. (1) The lateral hypothalamic area (LHA) has been known as the "feeding center". Electrical and chemical stimulation of the LHA elicit feeding behavior. This area contains a specific group of neurons which are sensitive to glucose, metabolites and hormones which are involved in fedding control. The majority of LHA glucose-sensitive neurons of the monkey decreases in activity during bar-press (food acquisition) and/or reward (food consumption) periods, while glucose-insensitive neurons mainly show excitatory response to cue signals which guide task performance. The task-related firing patterns are differentially regulated by catecholamines and opiod : β-adrenoceptors and opioid receptors are involved in modulation of bar press- and reward-related firing decrease, respectively, while dopamine is related to cue recognition and initiation of food acqusition. (2) The LHA is also involved in promotion of male sexual behavior, however, the medial preoptic area (MPOA) is the main neural substrate of male sexual behavior in the vertebrate. Neuron activity of the MPOA during sexual behavior is intimately related to the level of sexual arousal in the male monkey. Some MPOA neurons of the female monkey also show similar activity pattern during sexual behavior and activity of female MPOA neurons are affected by male's mating acts. (3) The dorsomedial hypothalamus (DMH) is involved in execution of mating acts in the male monkey. DMH neuron activity shows synchronized excitation during mounting and thrusting. (4) The ventromedial nucleus of the hypothalamus (VMH) has been thought as the center for female sexual behavior and as the "satiety center". VMH stimulation fascilitates female sexual behavior but suppresses feeding behavior in the monkey as well as lower mammals. VMH neurons are excited during presenting that is female sexual behavior of the monkey. A particular type of neurons in the VMH which is characterized by large cell soma and well developed dendrites shows excitatory response to glucose as well as to estrogen, which suggests neural substrates to cntrol feeding and sexual behaviorlind functionally and morphologically. In a hungry state, neural circuit promoting male sexual behavior may be activated, while female sexual activity may be fascilitated in a satiety state.
日本心身医学会の論文
1991-01-08

摂食行動・性行動の神経生理(心身医学の基礎研究)(第31回日本心身医学会総会)

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