空腹、満腹の生理調節 : 内在性短鎖有機酸に対する体液性応答

概要

論文の詳細を見る
Endogenous organic acids, i.e., 2-deoxytetronate (2-DTA), 3-deoxypentonate (3-DPA) and 3-hydroxybutyrate (3-HBA), have been demonstrated to induce elicitation and/or cessation of feeding behavior. In the present study, humoral responses to these organic acids were inverstigated. Ten μl volumes of organic acids, at a dose of 2.50 μ mol, 1.50 μmole physiological saline were administered into the third ventricle of the rat. Blood samples were collected from a chronically inplanted intra-right atrial catheter under the unanesthetized and unrestrained conditions. Plasma glucose, insulin and free fatty acid (FFA) were evaluated in response to these organic acids. 3-DPA raised plasma glucose and FFA initially, and their levels subsequently fell to those of the saline controls. 3-HBA initially induced the hyperglycemia as well as the hyperlipidemia preceded by the transient hyperinsulinemia. Succeeding to this initial period, the FFA level gradually, decreased below that of the controls. 2-DTA induced the hyperlipidemia, but not the hyperglycemia nor the hyperinsulinemia. Time variations of these humoral factors following intra-third ventricle administration of 3-DPA or 3-HBA were compatible with the previous results obtained both in the behavioral and electrophysiological studies.
日本心身医学会の論文
1983-08-01