心身症とカテコールアミン(心身症における情動と内分泌3第15回日本精神身体医学会総会シンポジウム)

概要

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The modification of sympathetic activity was studied in rats under the psychological stress, such as tone stimulus, electric shock and warning tone followed by the shock. The developement of body weight was undergrown in all these groups as compared to controls during 3-week observation period. Furthermore, the catecholamine content in various organs, especially heart, spleen and adrenal galnds, was also reduced. These reductions were prominent in electric shock, and tone and shock group for an experimental period of one week, but no more significant reductions were oberved thereafter.On the other hand, changes of sympathetic activity in patients with neurocirculatory asthenia (NCA), in which the psychological factors play an important role in its origin, was suspected. The urinary excretion of catecholamine and serum Dopamine-β-Hydroxylase activity (DBH) in resting state showed higher values in patients with NCA compared to those of normal subjects. In addition, the significant increases in urinary excretion of catecholamine and serum DBH activity were observed after the administration of pilocarpine.These results indicate that the sympathetic hyperactivity participates in formation of clinical symptoms in NCA.
日本心身医学会の論文
1975-02-01