出血時の交感神経活動の変容とそれにおよぼす副腎皮質ホルモンの影響に関する研究

概要

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With the purpose of investigating the pathophysiological significance of sympathetic activity in hemorrhagic shock, renal sympathetic nerve-impulses, blood pressure and cardiac rate were observed in rabbits in which mean blood pressure was lowered to 50 mmHg by means of exsanguination. Catecholamine concentrations and dopamine-B-hydroxylase activities in plasma were also measured as an index of sympathetic activity. Furthermore, therapeutic effects of blood transfusion and corticosteroids on these parameters were examined. 1) Reduction of blood pressure with significant tachycardia and sympathetic hyperactivity was observed with bloodletting. 2) Transfusion of heparinized autoblood was performed to the exsanguinated rabbits with twothirds of volume of the bled blood. The reduced blood pressure and increased sympathetic activity were transiently recovered to the nearly normal levels, and subsequently both of them returned to the exsanguinated levels. 3) Pretreatment with hydrocortisone was effective for sustaining the recovered blood pressure and lowered hyperactivity of sympathetic nerve after blood transfusion. These results indicate that the sympethetic hyper-activity plays an important role on the improvement of hemodynamic changes in hemorrhagic shock, and corticosteroids may be effective in recovery from the state of hemorrhagic shock probably due to a so-called permissive effect of corticosteroids on sympathetic activity.
神戸大学の論文