電気的に制御されたグルタミン酸放出デバイス

概要

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An electrically controlled L-glutamate (neurotransmitter) release device was constructed by assembling an actuator and polyelectrolyle gel microparticles. The actuator consisted of a cell with two graphite carbon electrodes. The actuator was filled with polyallylamine quaternary salt gel microparticles swelled with L-glutamic acid aqueous solution. The polyallylamine quaternary gel was specially designed and synthesized to be suitable for the swelling with L-glutamic acid. The gelmicroparticles shrunk and released L-glutamic acid under a d.c. electric field applied to the actuator through the electrodes. The amount of L-glutamic acid released from the actuator increased time - and voltage - dependently by increasing the applied voltage. It was found that there was a critical voltage to the shrinkage of the gel, that is, no shrinkage was observed below 2V. The voltage-dependent release of L-glutamic acid can be applicable to some medical devices such as nerve stimulation devices.
東海大学の論文
2001-03-30