ベンゾジアゼピン系薬剤による静脈内鎮静法の比較

概要

論文の詳細を見る
The usefulness and characteristics of diazepam, flunitrazepam, and midazolam, a benzodiazepine derivative, in intravenous sedation during oral surgical procedures under local anesthesia were studied for 31 patients (10 diazepam, 13 flunitrazepam, and 8 midazolam sessions). In intravenous sedation, cardiovascular function (rate pressure product: RPP; heart rate×peak systolic pressure), antianxiety (Face Anxiety Scale: FAS), respiratory depression (SpO_2), and amnesic reactions were measured. The cardiovascular function was best stabilized with flunitorazepam. These were no case of RPP above 15,000, and 15.4% were above 12,000. In 50% of the patients FAS after sedation with midazolam was low, and midazoalm showed the best antianxiety reaction. Respiratory depression was small with flunitrazepam. Most of the patients could not remember things shown to them after midazolam injection. We concluded that diazepam had the least effect of the three benzodiazepine derivatives. Flunitlazepam resulted in little respiratory depression, and the most stable cardiovascular function. Midazolam was most effective for antianxiety and amnesic reactions.
北海道医療大学の論文
1997-06-30