<総説> 血中コレステロール濃度調節機構に関する最近の分子生物学的研究 : コレステロールの胆汁酸への異化を中心として

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In this article, the mechanisms for maintaining a homeostasis in blood cholesterol level in mammals, focusing on metabolic change of cholesterol to bile acids, are reviewed. Blood cholesterol is maintained at a constant level by many factors. One of the important factors is a hepatic conversion of cellular cholesterol to bile acids, which play important roles in the digestion and absorption of dietary lipids in the gastrointestinal tract. On the synthesis of bile acids from cholesterol, cholesterol 7 α-hydroxylase plays a key role in the process. Recent progresses in the mechanisms for keeping a constant blood cholesterol level, an outline of bile acid synthesis, purification and assay methods of the enzyme are reviewed. The hormonal and dietary regulations in the expression of mRNA for the enzyme are also discussed.
三重大学の論文