胎盤組織におけるNK細胞障害の新たな負の制御因子Cho-1抗原の発現と意義

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There have been many reports describing the possible mechanism by which the fetus expressing paternally-derived allogeneic antigens is not rejected by the maternal immune system. Recently, it has been suggested that MHC class I molecules such as HLA-G act as the potent negative regulator in the cytotoxic mechanism of natural killer (NK) cells. More recent studies also indicated that there may be non-MHC molecules that function as the negative regulator in NK cytotoxicity. We previously reported such non-MHC molecules and designated one of them as Cho-1 antigen. This antigen is expressed in NK-resistant but not in NK sensitive cell lines. In the current study, we analyzed and compared Cho-1 antigen expression in placental tissues of the early phase (2-3 months) of successful pregnancy (artificial abortion) and spontaneous abortion cases. First, our immunohistochemical data indicated that Cho-1 antigen is clearly expressed in the cytoplasm as well as the nucleus of chorionic villi from the successful early phase of pregnancy, and is weakly expressed in those from spontaneous abortion. It is well expressed in the late phase (9-10 months of pregnancy) of placental tissue as well. Second, very interestingly, Cho-1 antigen was expressed on the cell surface of the chorionic cells of all nine cases of successful pregenancy, whereas it was not in any of the nine cases of spontaneous abortion. Thus, our study suggests that Cho-1 antigen may contribute as a negative regulator of NK cytotoxicity in the successful pregnancy of the fetus.
札幌医科大学の論文
1999-06-01

胎盤組織におけるNK細胞障害の新たな負の制御因子Cho-1抗原の発現と意義

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