<血行動態に関する研究>WKYとSHRSPの大動脈の内皮性調節におけるアラキドン酸代謝産物の役割

概要

論文の詳細を見る
The endothelium controls vascular smooth muscle contractions by releasing contracting (EDCF) and relaxing factors (EDCF). Some of these factors are synthesized from arachidonic acid through the cyclooxygenase pathway. We studied effects of indomethacin, a cyclooxygenase inhibitor on endothelium-dependent contraction and relaxation in the aorta of WKY and SHRSP. Noradrenaline-induced contractions were depressed by indomethacin and the depression was greater in the preparation from SHRSP than that from WKY. L-nitro arginine potentiated the contraction and attenuated the effect of indomethacin. These results suggest that NO is involved in the action of vasoactive arachidonic acid cascade products. The degree of involvement may differ between WKY and SHRSP aorta.
近畿大学の論文
1994-12-30