<基礎的研究発生病理>SHRSP静脈平滑筋のノルアドレナリン反応性について

概要

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Effects of noradrenaline on the smooth muscle of the portal vein from normotensive rats (WKY) and hypertensive rats (SHRSP) were compared. Noradrenaline increased the amplitude of spontaneous contraction, concentration dependently, in both the WKY and SHRSP preparations. At high concentrations of noradrenaline, WKY portal veins showed remarkable and sustained increase in basal tension, while the increase in basal tension was usually slight and transient in SHRSP. Desmethylimipramine shifted the noradrenaline concentration-contraction relation to the left by inhibiting the uptake mechanism, both in WKY and SHRSP, but basal tension increase could not be observed in SHRSP even after this treatment. Alpha-1-agonist phenylephrine produced a similar effect on basal tension of portal veins from WKY and SHRSP. Increase of contraction height was abolished by alpha-1 antagonist prazosin, both in WKY and SHRSP. Increase in K concentration, or inhibition of K conductance in the presence of noradrenaline, induced an increase of basal tension in SHRSP. These results suggest that the difference in K conductance is a cause of the difference in the response to noradrenaline.
近畿大学の論文
1988-12-30