Stimulating and potentiating effects of sodium nitroprusside on the guinea-pig vas deferens and their comparison with the effects on the portal vein and the taenia coli.
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Sunano, S. <I>Stimulating and potentiating effects of sodium nitroprusside on the guinea-pig was deferens and their comparison with the effects on the portal vein and the taenia coli.</I> Japanese Journal of Smooth Muscel Research, 1984, 20 (1), 25-33.-The effects of sodium nitroprusside on the electrical and mechanical properties of the guinea-pig was deferens were studied and compared with those on the portal vein and the taenia coli. Sodium nitroprusside at concentrations higher than 0.5mM caused depolarization of the membrane of the was deferens and initiated spontaneous contrac-tions, while spontaneous contractions of the portal vein were blocked by similar concentration of the drug. Noradrenaline-and carbachol-induced contractions of the was deferens were markedly potentiated by sodium nitroprusside, whereas the nora-drenaline-induced contraction of the portal vein was suppressed by the same concentration of the drug. Increasing the K<SUP>+</SUP> concentration by 15 to 30mM caused a similar potentiation of the contraction by noradrenaline or carbachol in the was deferens.<BR>When sodium nitroprusside was applied during the course of noradrenalineor carbachol-induced contracture, contraction was observed in the was deferens, while relaxation was induced in the portal vein and taenia coli. In either case, however, the addition of Ca caused a relaxation of the preparations.<BR>These results suggest that the membrane depolarization may be involved in the stimulating effects sodium nitroprusside in the guinea-pig was deferens.
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