SHRSP門脈縦走筋の収縮力に関する検討

概要

論文の詳細を見る
Contractions of the longitudinal smooth muscle of portal vein were compared between normotensive Wistar Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP). Contraction amplitude of the spontaneous contraction of SHRSP portal vein was higher than that of WKY. Further, electrical activity of the muscle cells was recorded with microelectrode. Spontaneous spike activity appeared in bursts and the number of spikes in each burst was greater in SHRSP portal vein than in WKY portal vein. No significant differences were observed in the resting membrane potentials. Amplitude of the phasic and the tonic component of K-contracture was also higher in SHRSP. Part of the contraction was inhibited by adrenergic blocker. Area of the longitudinal muscle layer was greater in SHRSP portal vein. The contractile force per unit muscle area in the presence of adrenergic blocker was also larger in SHRSP portal vein than that in WKY portal vein. These results suggest that changes both in spontaneous electrical activities and contractile force of the muscle cells may contribute to the differences in spontaneous contraction amplitude between WKY and SHRSP.
近畿大学の論文
1987-12-30