SHRSPおよびWKY血管平滑筋のNa, K-ATPase阻害剤による収縮(I 発生病理)(A 基礎的研究)

概要

論文の詳細を見る
Effects of two typical Na, K-ATPase inhibitors, vanadate and ouabain, on the vascular smooth muscles from SHRSP and WKY were compared. Both agents induced contraction with similar potency varying among the types of arteries. However, differences of contractile effects between vanadate and ouabain were also observed in the time courses of contraction, the involvement of intrinsic catecholamine, the mode of potentiation by partial depolarization and the dependence on extracellular Ca. Besides continuous infusion of vanadate rose the systolic and diastolic blood pressure of rats. These results suggest that vanadate and ouabain induce contraction of the vascular smooth muscle in different manners. However, both agents may induce a vasocontraction which leads to hypertension.
近畿大学の論文
1985-12-30