<基礎的研究発生病理>血管平滑筋収縮の内皮による調節と高血圧自然発症ラットの血管における異常

概要

論文の詳細を見る
Noradrenaline-induced contraction was potentiated by the removal of endothelium and the potentiation was greater in the aorta of Wistar Kyoto (WKY) rats than in that of stroke-prone spontaneously hypertensive rats (SHRSP). N^G-nitro-L-arginine (L-NNA, 100μM), which inhibits nitric oxide (NO) synthesis, also potentiated the noradrenaline-induced contraction in the endothelium-intact preparation. The effect of L-NNA was greater in the WKY preparation. Acetylcholine-induced relaxation in the endothelium-intact aorta was impaired in the SHRSP preparation. Phenylephrine- and clonidine-induced contractions were augmented by pretreatment with L-NNA or removal of endothelium. These findings indicate that the vascular endothelium modulates the noradrenaline-induced contraction by releasing NO through α_<1-> and α_<2-> adrenergic receptors. The depression of noradrenaline-induced contraction by the endothelium was augmented by the repetition of the initiation of the contraction. The augmentation of the depression was less prominent in the SHRSP aorta. This also suggests that the release of NO through these adrenergic receptors is reduced in the aorta of SHRSP.
近畿大学の論文
1993-12-30