<予防および治療>高コレステロール血症に対するHMG-CoA reductase inhibitor(プラバスタチン)の有用性

概要

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We used HMG-CoA reductase inhibitor, Pravastatin for hypercholesterolemia for 12 months and evaluated its effect. Total cholesterol was significantly lowered after a month of treatment and the lower level lasted for 12 months. LDL-cholesterol was more reduced than total cholesterol. On the other hand, HDL-cholesterol tended to rise a month later and was significantly increased after 6 and 12 months. Reduction of LDL-cholesterol was reflected in a marked decrease of apo B. Other apo-lipoproteins showed no significant changes. Triglyceride was not decreased by pravastatin in phenotypes II a and II b. Pravastatin in combination was very effective for most cases of familial hypercholesterolemia for which other drugs had been in-effective.
近畿大学の論文
1991-12-30