<原著>糖尿病におけるHbA_1値測定の臨床的評価について

概要

論文の詳細を見る
Hemoglobin A_1 (HbA_1) or glycosylated Hb, is generated from HbA non enzymatically and irreversibly by posttranslational glycosylation of HbA throughout the life-span of erythrocytes. The generation depends on blood glucose levels. Though HbA_1 consists of HbA_<1a>, A_<1b> and A_<1c>, we measured the sum of these three components as HbA_1 values (%) by mini-column procedure kit in 67 diabetics (mean age 53.0=1.5 years) who were on a diet or treated with antidiabetic drugs or insulin preparation in outpatients' department. In addition to HbA_1 values, fasting blood sugar levels (FBS) and 24-hr. urinary sugar values (US) were measured. In the whole diabetics studied, HbA_1 values were correlated highly significantly with FBS one month before sampling of HbA_1 (r=0.7l9,p<0.001), and HbA_1 values were also correlated highly significantly with US one month before sampling of HbA_1 (r=0.660,p<0.001). The correlation of HbA_1 values with FBS and US in insulin-treated group was less significant than those in other treatments groups (r=0.165-0.679,p : NS-<0.01). In follow-up studies, HbA_1 values were found to be decreased in parallel with FBS in a delay of about one month. We concluded that HbA_1 values reflected the blood sugar levels since about one month before the sampling of HbA_1 and were useful as an index of the long-term diabetic control. However, HbA_1 values cannot always be useful as an index of diabetic control in the cases with fluctuating blood sugar levels.
近畿大学の論文
1983-03-25

<原著>糖尿病におけるHbA_1値測定の臨床的評価について

スポンサーリンク

概要

著者

関連論文

スポンサーリンク