<基礎的研究発生病理>SHR-SPのプラスミノーゲン・アクチベータについて

概要

論文の詳細を見る
The present study was undertaken to purify plasminogen activator (PA) from the brain and kidney tissues of spontaneously hypertensive rat-stroke prone (SHR-SP) and its ancestor, Wistar-Kyoto rat (WKY), since the pathogenesis of stroke remains still unclear. Electrophoretic enzymography of purified PA from the tissues of both SHR-SP and WKY showed three bands with the molecular weight of 72 kDa, 55 kDa and 33 kDa, respectively. The latter two PAs showed UK type antigenicity and the former, t-PA type one. The PA content of SHR-SP was almost three times higher than that of WKY both in the brain and kidney. These results indicate that qualitative difference in PA was not observed, but that quantitative difference of PA in the brain and kidney tissues may exist between SHR-SP and WKY, which implies that PA may play an important role in the stroke.
近畿大学の論文
1986-12-30