<原著>ウサギ下肢における血管切断と再縫合による血液凝固線溶系の動態

概要

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Cut and anastomosed male rabbit femoral artery were prepared to examine the effects on blood flow and coagulation-fibrinolysis. Cut and anastmosis were performed with the microsurgical technique. Blood samples were taken before and after the operation at 1,3,5 and 7 days, and subjected to the measurements of plasminogen activator activity, plasminogen, fibrinogen, antithrombin-III and α_2-plasmin inhibitor. Blood flow was measured using H_2-gas clearance method, which decreased immediately after the operation and then increased gradually. The plasminogen activator activity which was measured with ^<125>I-fibrin plate method showed two typical changes : one group showed a decreased plasminogen activator activity after the operation, and the other group showed the initial decrease of plasminogen activator activity followed by the rebound increase. In the former group, α_2-antiplasmin increased remarkably throughout the experiment and antithrombin-III increased. Plasminogen and fibrinogen increased after the operation, reflecting an acute phase reactant. Using thromboelastogram, the inhibitory activity of fibrinolysis were determined with rabbits and human blood respectively. The rabbit blood showed almost ten times higher inhibitory activity than human blood. These results obtained above might be an indicator of testing feasibility of anastomosis.
近畿大学の論文
1984-12-30