<原著>ケタミンのネコ脊髄後角第V層型細胞活動におよぼす影響

概要

論文の詳細を見る
The site of antinociceptive effect of ketamine was studied in the temporary spinalized (cold blocked) cat. The extracellular recording from the lamina V type neuron of the spinal dorsal horn was carried out at the 7th lumbar segment using tungusten microelectrode. The neurones were stimulated peripherally by the pinch of the ipsilateral foot. In the intact state the administration of ketamine 10mg/kg (ketamine hydrochloride 11.5mg/kg) (i.v.) suppressed significantly (p<0.01) spontaneous activities and pinch induced activities compared to the control values. In the spinal state spontaneous activities and pinch induced activities were suppressed significantly (p<0.01) compared to the values of the spinal state before the drug. These results suggest that ketamine 10mg/kg shows potent direct suppressive effect at the spinal dorsal horn to the pinch stimulation.
近畿大学の論文
1985-03-25