Fluctuation of Cyclic AMP and Cyclic GMP Levels in the Brain and in the Uterus Endometrium during the Estrous Cycle of Rats
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Contents of cyclic AMP and cyclic GMP in seven regions of the brain and the uterus endometrium (UEM) were determined during the estrous cycle in intact female rats. Effects of 17β-estradiol (EST) and progesterone (PRG) on these cyclic uncleotides contents in the brain and UEM were also studied in ovariectomized rats. Increased cyclic AMP content was observed in proestrus (P) and estrus II (E II) stages in most regions of the brain. A significant increase in cyclic GMP content was observed in cerebellum, midbrain and hippocampus in E II stage. However, the magnitude of the change was much smaller than that of cyclic AMP. In UEM, cyclic AMP content was increased in P stage and was decreased in E II stage. Cyclic GMP content increased in P and estrus I (E I) stages. Thus, the ratio of (cyclic AMP)/(cyclic GMP) in UEM fell in P, E I, E II and metestrus stages showing a U-shaped curve. EST induced significant increases in cyclic AMP content in hypothalamus, midbrain and UEM, and in cyclic GMP content in cortex, hypothalamus and striatum. PRG produced no significant changes in these cyclic nucleotides contents in the brain, while in UEM, PRG produced significant decrease in cyclic AMP and an increase in cyclic GMP content. Thus, the ratio of (cyclic AMP)/(cyclic GMP) was significantly increased by EST and decreased by PRG in UEM. These data indicate that the cyclic AMP content in the brain fluctuates during the estruos cycle and that EST appears to be involved at least in part in this fluctuation. In UEM, it is suggested that the changes in cyclic AMP and cyclic GMP refer to the action of EST and PRG.
- 共立薬科大学の論文
- 1988-03-25
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