The influence of cold stress and corticosterone pretreatment on norepinephrine and catechol-O-methyltransferase activity in hypothalamus of rat

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In this study we explored the influence of exposure to cold stress (4℃) on the norepinephrine (NE) content and the activity of catechol-O-methyltransferase (COMT) in the rat hypothalmus, and the effect of pretreatment with corticosterone (CS, 5mg/kg, i. p.) on the changes in the NE content and COMT activity induced by stress. A marked decrease of NE content in the hypothalamus was observed during the first 15min of exposure to 4℃, with a subsequent recovery. The decrease in NE content by stress was blocked by the pretreatment with CS. COMT activity at 15min of cold exposure decreased by about 15% as compared with the normal level and it remained at the decreased level during the ensuing period up to 90min. CS pretreatment did not affect the decrease in COMT activity induced by cold stress. The decrease of NE content in the hypothalamus by stress may by caused by the increase of turnover rate and its recovery may by due to the elevation of synthesis through the high level of plasma CS in consequence of the increased release. COMT activity is not directly related to NE decrease induced by stress and the plasma CS concentration.
共立薬科大学の論文
1988-03-25