解熱薬の効力検定法に関する基礎的研究

概要

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For the estimation of the antipyretic potency, it is important to keep the body temperature of the experimental animals at the constant plateaued level. In these experiments, we proposed a method which will be able to solve this problem by the following proceedures. The normal rabbit was fixed using a neck stock so designed that the rabbit sit in a normal posture. Immediately after fixation without waiting the recovery of the lowered body temperature by the fixation, 0.4% Vaccium Typhosum Epidemicum (JP) solution was injected into auricular vein in a doses of 1ml per Kg body weight. One hour later, total 20ml of 2.0% vaccine was injected in a constant speed for two hours using a motor-drived syringe. For the next four hours 40ml of 4.0% vaccine solution was given in the same way. Then, the body temperature went up and kept the plateaued level from about 3 hours after first injection to the finishing of the vaccine-treatment. So, it was able to demonstrate the antipyretic effect when some drugs were inyjected This method was considered to be sensitive enough and to be able to save the time.
共立薬科大学の論文
1967-05-20