<原報>脳内 Monoamine Oxidase と性ホルモン

概要

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The effects of sex hormones on the level of MAO activity of brain were investigated using the S-D strain rats. The mitochondrial fraction was prepared from homogenized whole brain tissues and the MAO activity toward tyramine was measured by oxygen electrode method. The enzyme activity increased progressively until 4 weeks after birth and there was no significant difference in activity between male and female groups. Thereafter, the activity level increased slightly in male animals, but the level remained fairly constant or rather decreased in female animals. The activity was inhibited by ad ministration of 17β-estradiol and was not affected by administration of testosterone in adult male rats. Castration resulted in inhibition of the activity in male and increasing of the activity in female rats. The inhibition of MAO activity by castration in male rats was followed by complete recovery with the administration of testosterone. While the increasing of the activity by oophorectomy was not affected by the administration of testosterone or 17β-estradiol. Also MAO activity of brain mitochondria was inhibited in vitro by 17β-estradiol in male rats.
1975-02-25