<原報>合成副腎皮質ホルモンの生物学的活性に関する研究〔第 3 報〕

概要

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The present investigations were undertaken to determine the anti-inflammatory and other activities of 21-chloro-9α-fluoro-11β-methl-17α-propionyloxy-pregna-1,4-diene-3,20-dione (clobetasol propionate, abr. CBP) : edema and cotton pellet granuloma inhibiting, androgenic-anabolic, estragenic and anti-estragenic activities The following results were obteined : 1) In the cases of the granuloma inhibition potency test by the method of the cotton pellet implantation in adrenalectomized rat, CBP was 2.3 times greater than betamethasone-17-valerate. 2) In carrageenin and formalin edema-inhibition test, CBP was about 100 times as potent as hydrocortisone and about 2 times the activity of betamethasone-17-valerate. 3) Thymus involuting activity of CBP in mice was 32 times as potent as hydrocortisone and 3.5 times greater than betamethasone-17-valerate. 4) Increasing of sodium and potassium excretion and of urine volume were observed by CBP. From a consideration of these results, it seems most reasonable to conclude that clobetasol propionate has marked anti-inflammatory activities with no sodium retention and also that it has no androgenic-anabolic and estrogenic activities.
共立薬科大学の論文
1974-02-25