<原報>ラット脳内 Tyrosine Hydroxylase に関する研究(第 1 報) : Tyrosine Hydroxylase の脳内分布と性周期に伴う変動

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Tyrosine hydroxylase (TH) in rat brain during different phases of the estrous cycle and the effects of 17β-estradiol (E) and progesterone (P) on TH were studied using a modification of Waymir's method. Seven brain regions were dissected from adult SD rats, maintained on a 11hr light-13hr dark lighting schedule, according to the method of Glowinski and Iversen. The activity was highest at proestrus and then decreased steadily to the lowest levels at estrus II in all of seven regions. In oophorectomized rats, E in olive oil (50 μg/kg, twice a day for 2 days, s. c.) decreased the activity in all brain regions, except midbrain and P in olive oil (1 or 2mg/kg, given in the same way as E) was more effective in decreasing the activity except in the striatum at the dose of 1mg/kg. However, when P was injected concomitantly with E, the activity showed the tendency toward restoration, or rather to increase, though such was not necessarily dose dependent. The participation of these steroids in the gonadotropin releasing mechanisms through the action on TH is doubtful.
共立薬科大学の論文