Regulation of Anoikis <Review>

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概要

• 論文の詳細を見る

• Normal epithelial and endothelial cells require attachment to extracellular matrix (ECM) proteins to grow or survive. In these anchorage -dependent cells, loss of interaction with the ECM proteins triggers apoptosis which is termed anoikis. Anoikis undoubtedly plays an essential role in the development and organization of normal tissues through its inhibitory effect on unfavorable cellular proliferation at inappropriate locations. In this regard, anoikis contributes to the maintenance of the physiological state. Importantly, disturbance of anoikis may allow cell proliferation at inappropriate sites and thus may be tightly linked to cancer development. Indeed, we have found that suppression of anoikis promotes peritoneal dissemination or metastasis of several carcinoma cells. These data imply that clarification of the molecular mechanism which regulates anoikis will, in turn, greatly help the regulation of cancer progression. Here we summarize recent advances in the field of anoikis regulation.

• 札幌医科大学の論文

著者

• IMAI Kohzoh

  First Department of Internal Medicine, Sapporo Medical University

• Imai K

  Sapporo Medical University

• Imai Kohzoh

  札幌医科大学 生化学

• Imai Kohzoh

  鹿児島大学 医歯学総合研究科病理学第2

• ADACHI Masaaki

  First Department of Internal Medicine, Sapporo Medical University

• Adachi M

  First Department Of Internal Medicine Sapporo Medical University

• Adachi Masaaki

  札幌医科大学 第1内科

• Imai Kohzoh

  Department Of Internal Medicine (section 1) Sapporo Medical University School Of Medicine

• Imai Kohzoh

  First Department Of Internal Medicine Sapporo Medical University

• MINAMI Takae

  First Department of Internal Medicine, Sapporo Medical University

• Yamamoto H

  Department Of Gastroenterology Akita Red Cross Hospital

• Minami Takae

  First Department Of Internal Medicine Sapporo Medical University

• Sakamoto Hiroki

  Sapporo Clinical Laboratory

• Idogawa Masashi

  First Department of Internal Medicine, Sapporo Medical University School of Medicine

• Nishimura Susumu

  First Department of Internal Medicine, Sapporo Medical University School of Medicine

• Yasui Hiroshi

  First Department of Internal Medicine, Sapporo Medical University School of Medicine

• NISHIMURA SUSUMU

  Department of Internal Medicine, Sapporo Shirakabadai Hospital

• Adachi Masaaki

  First Department Of Internal Medicine Sapporo Medical University

• Yasui Hiroshi

  First Department Of Internal Medicine Sapporo Medical University School Of Medicine

• Adachi Masaaki

  First Department Of Internal Medicine Sapporo Medical University School Of Medicine

• Nishimura Susumu

  Sapporo Medical Univ. School Of Medicine Sapporo Jpn

• Nishimura Susumu

  First Department Of Internal Medicine Sapporo Medical University School Of Medicine

• Idogawa Masashi

  First Department Of Internal Medicine Sapporo Medical University School Of Medicine

• Yamamoto H

  First Department Of Internal Medicine Sapporo Medical University

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