Prenatal ionizing radiation-induced apoptosis of the developing murine brain with special references to the expression of some proteins

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概要

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• Apoptosis induced by ionizing irradiation of the developing mouse brainwas investigated by using histology, analysis of DNA fragmentation on agarose geland electron microscopy. A TUNEL-labeled index (L. I.) was calculated from theterminal deoxynucleotidy1 transferase (TdT)-mediated dUTP nick-end labeling(TUNEL) assay in 4 specific regions, cortical plate, intermediate zone, subependymalzone, and subependymal germinal matrix. The kinetics of apoptosis associated proteinwas examined by western blotting and immunofluorescence. C57BL/6J mice pregnanton embryonic day 14 (E14) were exposed to a single dose of 1.5-Gy irradiation.Irradiated fetal brains at E15 and E17 showed extensive apoptosis with morphologicalcharacteristics. In all 4 regions, L. I. was greater in irradiated brains than in controlbrains at E15 and E17. Most of TUNEL-labeled cells expressed a mature neuronalmarker (NeuN) and Bax protein, which is up-regulated in irradiation-inducedapoptosis. Ionizing radiation moderately enhanced expression of Bax. Bcl-xL, and Cpp32proteins. Postnatal irradiated mice showed microencephaly as compared toage-matched mice and the weight of whole body including brain decreasedmoderately.

• 神戸大学の論文

著者

• 林 祥剛

  神戸大学大学院微生物感染症学講座感染病理学分野

• Hayashi Yoshitake

  神戸大学医学系研究科

• Hayashi Yoshitake

  Division Of Surgical Pathology Department Of Biological Informatics Kobe University Graduate School

• Imai Y

  神戸大学医学部

• Imai Yukihiro

  神戸大学 医系研究 生体情報医

• Sasaki R

  Keio Univ. School Of Medicine Tokyo Jpn

• Imai Yukihiro

  神戸大学医学系研究科

• Itoh Hiroshi

  神戸大学医学系研究科

• Kitamura Makiko

  神戸大学医学部

• Itoh Kyoko

  神戸大学医学部

• Matsumoto Akira

  神戸大学医学部

• Sakaki Ryohei

  神戸大学医学部

• Hayashi Yoshitake

  神戸大学医学部

• Itoh K

  神戸大学医学部

• Ito Hiroshi

  神戸大学医学系研究科

• Matsumoto A

  神戸大学医学部

• Ito Kyoko

  神戸大学医学部

• Sasaki Ryohei

  神戸大学医学部

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