Immunohistochemical study of P53, PCNA and AFP in hepatocellular carcinoma, a comparison between Indonesian and Japanese cases
スポンサーリンク
概要
- 論文の詳細を見る
Mutations of p53 as a tumor suppressor gene in hepatocellular carcinoma (HCC) have been reported to occur with varying frequency in different geographic regions, which might be different etiology for HCC. Overexpressions of p53 (well known for its implications in mutations of the p53 gene), PCNA and a-fetoprotein (AFP) have been reported to be associated with carcinogenesis and/or tumor progression and poor prognosis in various types of cancer. To estimate the geographical difference of the p53 gene, PCNA and AFP in HCC, we examined 14 Japanese HCC cases, 8 Indonesian HCC cases, and 27 Indonesian chronic active hepatitis (CAH) or liver cirrhosis cases, using immunohistochemical approaches. Overexpression of p53 was identified in 37.5% of Japanese HCC, in 62.5% of Indonesian HCC and none in CAH. The mean PCNA Labeling Index of Japanese HCC, Indonesian HCC and CAH was detected in 48.6%, 30.4%, and 43.5%, respectively. AFP was detected in 35.7% of Japanese and 25% of Indonesian HCC. The rate of p53 overexpression in Indonesian HCC was as high as in HCC of southern part of China, which might share the similar etiology in both regions.
- 神戸大学の論文
著者
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MISKAD Upik
First Division, Department of Pathology, Kobe University School of Medicine
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Hayashi Yoshitake
神戸朝日病院 消化器科
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Hayashi Yoshitake
Division Of Surgical Pathology Department Of Biological Informatics Kobe University Graduate School
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Hayashi Yoshitake
Department Of Public Health Osaka City University Graduate School Of Medicine
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Hayashi Yoshitake
Division Of Molecular Medicine And Medical Genetics International Center Of Medical Research And Tre
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Hayashi Y
Kobe Univ. Graduate School Of Medicine
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Marwoto Wirasmi
Departlnent of Anatomical Pathology, Faculty of Medicine, Indonesia University
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Siregar Nuryati
Departlnent of Anatomical Pathology, Faculty of Medicine, Indonesia University
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Gani Rino
Department of Internal Medicine, Faculty of Medicine, Indonesia University
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Boedihusodo Unggul
Department of Internal Medicine, Faculty of Medicine, Indonesia University
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Nurdjanah Siti
Departlnent of Anatomical Pathology, Faculty of Medicine, Indonesia University
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Boedi Poernomo
Department of Internal Medicine, Faculty of Medicine, Airlangga University
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Hasan H.
Department of Internal Medicine, Faculty of Medicine, Airlangga University
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Akbar Nurul
Department of Internal Medicine, Faculty of Medicine, Indonesia University
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Noer H.
Department of Internal Medicine, Faculty of Medicine, Indonesia University
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Hayashi Yoshitake
Department Of Pathology Division Of Molecular Medicine & Medical Genetics Kobe University Gradua
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Noer H.
Department Of Internal Medicine Faculty Of Medicine Indonesia University
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Gani Rino
Department Of Internal Medicine Faculty Of Medicine Indonesia University
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Akbar Nurul
Department Of Internal Medicine Faculty Of Medicine Indonesia University
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Miskad Upik
First Division Department Of Pathology Kobe University School Of Medicine
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Boedi Poernomo
Department Of Internal Medicine Faculty Of Medicine Airlangga University
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Nurdjanah Siti
Departlnent Of Anatomical Pathology Faculty Of Medicine Indonesia University
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Miskad Upik
神戸大学 第1病理
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Siregar Nuryati
Departlnent Of Anatomical Pathology Faculty Of Medicine Indonesia University
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Marwoto Wirasmi
Departlnent Of Anatomical Pathology Faculty Of Medicine Indonesia University
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Boedihusodo Unggul
Department Of Internal Medicine Faculty Of Medicine Indonesia University
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Hasan H.
Department Of Internal Medicine Faculty Of Medicine Airlangga University
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