Antineutrophil Cytoplasmic Antibody-associated Vasculitis Complicating Graves' Disease: Report of Two Adult Cases
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概要
- 論文の詳細を見る
Two adult female patients with established Graves' disease were treated with propylthiouracil (PTU). One patient developed agranulocytosis, high fever of unknown origin and bilateral episcleritis. Another patient reported repeated attacks of common cold-like symptoms, polyarthralgia and skin purpura. There was no hematuria or proteinuria. Administration of PTU was withdrawn following identification of high myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) titer in the serum. Without steroids or immunosuppressive therapy, symptoms improved gradually in association with a fall in serum MPO-ANCA titer. We speculated that the symptoms of our two cases were due to MPO-ANCA associated vasculitis. MPO-ANCA positive vasculitis and glomerulonephritis are rare complications of PTU therapy, however, when these occur, the condition may become serious. Patients with Graves' disease treated with PTU should be carefully observed during therapy.
- 長崎大学の論文
著者
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Ashizawa K
First Department Of Internal Medicine Nagasaki University Hospital Of Medicine And Dentistry Graduat
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江口 勝美
長崎大学第一内科
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江口 勝美
聖マリアンナ医科大学附属難病治療研究センター ゲノム医科学 研究部門
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Eguchi Katsumi
First Department Of Internal Medicine Nagasaki University Hospital Of Medicine And Dentistry Graduat
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Abe Y
The First Department Of Internal Medicine Nagasaki University School Of Medicine
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SERA Nobuko
Department of Clinical Studies, Radiation Effects Research Foundation
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江口 勝美
長崎大学附属病院第一内科
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Sera Nobuko
The First Department Of Internal Medicine Nagasaki University School Of Medicine
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TOMINAGA Tan
the First Department of Internal Medicine, Nagasaki University School of Medicine
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Sera Nobuko
First Department of Internal Medicine, Nagasaki University School of Medicine
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Ejima Eri
The First Department Of Internal Medicine Nagasaki University School Of Medicine
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Tominaga Tan
The First Department Of Internal Medicine Nagasaki University School Of Medicine
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Usa Toshirou
The First Department Of Internal Medicine Nagasaki University School Of Medicine
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Ide Akane
The First Department Of Internal Medicine Nagasaki University School Of Medicine
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Ashizawa Kiyoto
First Department Of Internal Medicine Atomic Bomb Disease Institute Nagasaki University School Of Me
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Yokoyama Naokata
First Department Of Internal Medicine Atomic Bomb Disease Institute Nagasaki University School Of Me
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