<Originals>Oxygen radical formation by splenic macrophages in non-obese diabetic (NOD) mice
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概要
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In an attempt to determine the roles of oxygen radicals in the destruction of pancreatic β cells and in the development of diabetes, oxygen radical formation was measured in splenic macrophages from non-obsee diabetic (NOD) mice which had been treated with cyclophosphamide (CY). Oxygen radical formation in macrophages due to CY was enhanced both in NOD and ICR mice with a higher response in NOD than in ICR. Even in animals not receiving CY, NOD mice showed a significantly high level of oxygen radical formation in splenic macrophages as compared with the control ICR mice. CY enhanced the oxygen radical formation in NOD mice which reached a peak at 14 days after CY treatment after which it decreased. This enhancement by CY treatment was in part suppressed by silica, which is selectively toxic for macrophages. Mac-1 (CD11b/CD18) antigen on macrophages was augmented by CY, which was also suppressed by silica. Thus, the enhancement of oxygen radical formation and Mac-1 antigen in macrophages seems to contribute to the pathogenesis of CY-induced diabetes in NOD mice besides well-established roles by lymphoid cells.
著者
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Imamura M
Kinki Univ. School Of Medicine Osaka Jpn
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Imamura Minoru
Second Department Of Internal Medicine Kinki University School Of Medicine
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Aoki Noriko
2nd Division Department Of Internal Medicine Kinki University Faculty Of Medicine
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Aoki N
Department Of Endocrinology Metabolism And Diabetes Kinki University School Of Medicine
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Aoki Norihiko
Second Department Of Internal Medicine Kinki University School Of Medicine
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