Statistical Parametric Mapping for Effects of Verapamil on Olfactory Connections of Rat Brain in Vivo using Manganese-enhanced MR Imaging
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概要
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Purpose: We investigated the effect of verapamil on the transport of manganese in the olfactory connections of rat brains in vivo using statistical parametric mapping and manganese-enhanced magnetic resonance (MR) imaging. Methods: We divided 12 7-week-old male Sprague-Dawley rats into 2 groups of six and injected 10 μL of saline into the right nasal cavities of the first group and 10 μL of verapamil (2.5 mg/mL) into the other group. Twenty minutes after the initial injection, we injected 10 μL of MnCl2 (1 mol/L) into the right nasal cavities of both groups. We obtained serial T1-weighted MR images before administering the verapamil or saline and at 0.5, one, 24, 48, and 72 hours and 7 days after administering the MnCl2, spatially normalized the MR images on the rat brain atlas, and analyzed the data using voxel-based statistical comparison. Results: Statistical parametric maps demonstrated the transport of manganese. Manganese ions created significant enhancement (t-score = 36.6) 24 hours after MnCl2 administration in the group administered saline but not at the same time point in the group receiving verapamil. The extent of significantly enhanced regions peaked at 72 hours in both groups and both sides of the brain. The peak of extent in the right side brain in the group injected with saline was 70.2 mm3 and in the group with verapamil, 92.4 mm3. The extents in the left side were 64.0 mm3 for the group with saline and 53.2 mm3 for the group with verapamil. Conclusion: We applied statistical parametric mapping using manganese-enhanced MR imaging to demonstrate in vivo the transport of manganese in the olfactory connections of rat brains with and without verapamil and found that verapamil did affect this transport.
- 2011-06-01
著者
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Fujii Hitomi
Department of Internal Medicine, Tama-center Mirai Clinic
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Soma Tsutomu
Department Of Medical Engineering Division Of Applied Health Sciences Osaka University Medical Schoo
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Yamazaki Youichi
Department Of Medical Engineering Division Of Allied Health Sciences Osaka University Medical School
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Murase Kenya
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Faculty Of
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Kusakabe Yoshinori
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Faculty Of
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Okada Sakie
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Faculty Of
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Matsushita Taro
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Faculty Of
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Murase Kenya
Department Of Allied Health Sciences Osaka University Graduate School Of Medicine
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KURAKAWA Masami
Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty o
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KOTO Daichi
Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty o
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NAGATA Mamoru
Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty o
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Koto Daichi
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Faculty Of
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Nagata Mamoru
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Faculty Of
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Kurakawa Masami
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Faculty Of
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Soma Tsutomu
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Faculty Of
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Fujii Hitomi
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Faculty Of
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Yamazaki Youichi
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Faculty Of Health Science Graduate School Of Medicine Osaka University
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