Using BOLD Imaging to Measure Renal Oxygenation Dynamics in Rats Injected with Diuretics
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概要
- 論文の詳細を見る
Purpose: We used blood oxygenation level-dependent magnetic resonance imaging (BOLD MRI) to measure renal oxygenation dynamics in rats injected with diuretics and evaluated diuretic effect on renal oxygenation. Methods: We performed BOLD MRI studies in 32 rats using a 1.5-tesla MR imaging system for animal experiments. We intravenously injected rats with saline (n=7), furosemide (n=7), acetazolamide (n=6), or mannitol (n=6). For controls, 6 rats were not injected with drugs. We estimated the apparent transverse relaxation rate (R2*) from the apparent transverse relaxation time (T2*)-weighted images and measured the time course of R2* at 4-min intervals over approximately 30 min. Results: Compared with preadministration values, the R2* value did not change significantly in either the cortex or medulla in the control and mannitol groups but decreased significantly in the saline group; the R2* value significantly decreased in the medulla but did not change significantly in the cortex in the furosemide group; and the R2* value significantly increased in the medulla and significantly decreased in the cortex in the acetazolamide group. Conclusion: Our study results suggest that BOLD MRI is useful for evaluating the dynamics of renal oxygenation in response to various diuretics in the renal cortex and in the medulla.
- 日本磁気共鳴医学会の論文
- 2010-12-01
著者
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MURASE Kenya
Department of Medical Engineering, Division of Allied Health Sciences, Osaka University Medical Scho
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Murase Kenya
Department Of Medical Engineering Division Of Allied Health Sciences Osaka University Medical School
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Murase Kenya
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Faculty Of
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KUSAKABE Yoshinori
Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty o
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MATSUSHITA Taro
Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty o
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HONDA Saori
Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty o
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OKADA Sakie
Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty o
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Kusakabe Yoshinori
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Faculty Of
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Honda Saori
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Faculty Of
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Okada Sakie
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Faculty Of
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Matsushita Taro
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Faculty Of
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Murase Kenya
Department Of Allied Health Sciences Osaka University Graduate School Of Medicine
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