Development of a Noninvasive Method to Measure Intravascular and Intracardiac Pressure Differences Using Magnetic Resonance Imaging
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概要
- 論文の詳細を見る
Purpose: We developed a noninvasive method using magnetic resonance (MR) imaging to measure differences in intravascular and intracardiac pressure, and we investigated the feasibility of the methods use in a pulsatile flow phantom and human studies. Methods: We measured 3 velocity components using phase contrast MR imaging on a 1.5T MR scanner, used velocity data in Navier-Stokes equations to obtain pressure gradients, and directly integrated the in-plane pressure gradients to calculate pressure differences. To validate our method, we compared the pressure differences obtained by our method with the theoretical values obtained from an axisymmetric model of arterial stenosis. We also estimated the pressure differences in glass-tube phantoms simulating various vascular pathologies and in the left ventricle and aortic arch of a normal volunteer as clinical application. Results: The pressure differences obtained by our method agreed well with theoretical values obtained using the straight-tube phantom with stenosis of 45%, but we observed some differences when stenosis was 65%. We clearly observed variations in pressure differences at specific locations at various phases of a cardiac cycle in both phantom and human studies. Conclusion: This method appears useful for measuring intravascular and intracardiac pressure differences.
- 日本磁気共鳴医学会の論文
- 2008-09-01
著者
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UEGUCHI Takashi
Department of Radiology, Osaka University Hospital
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MURASE Kenya
Department of Medical Engineering, Division of Allied Health Sciences, Osaka University Medical Scho
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Murase Kenya
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Course Of H
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OKADA Koji
Department of General Surgical Science, and 21st Century COE Program, Graduate School of Medicine, G
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YOSHIDA Keita
Department of Medical Physics and Engineering, Division of Medical Technology and Science, Course of
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Murase Kenya
Department Of Medical Engineering Division Of Allied Health Sciences Osaka University Medical School
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Okada Kouji
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Course Of H
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Murase Kenya
大阪大学大学院医学系研究科保健学専攻
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Yoshida Keita
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Course Of H
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NAGAO Taisuke
Department of Medical Physics and Engineering, Division of Medical Technology and Science, Course of
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MIYAZAKI Shohei
Department of Medical Physics and Engineering, Division of Medical Technology and Science, Course of
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Nagao Taisuke
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Course Of H
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Ueguchi Takashi
Department Of Medical Physics Osaka University Graduate School Of Medicine
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Ueguchi Takashi
Department Of Radiology Osaka University Hospital
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Murase K
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Course Of H
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Miyazaki Shohei
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Course Of H
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Miyazaki Shohei
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Course Of H
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Okada Koji
Department Of Engineering Physics Electronics And Mechanics Graduate School Of Engineering Nagoya In
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Murase Kenya
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Course Of H
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Okada Koji
Department Of Applied Physics Tokai University
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Murase Kenya
Department Of Allied Health Sciences Osaka University Graduate School Of Medicine
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Murase Kenya
Department Of Medical Physics And Engineering Division Of Medical Technology And Science Course Of H
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YOSHIDA Keita
Department of Biological Sciences, Graduate School of Science and Engineering, Tokyo Metropolitan University
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