Effect of Age on the Association between Body Mass Index and All-Cause Mortality : The Ohsaki Cohort Study

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概要

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• Background: To clarify the effect of age on the association between body mass index (BMI) and all-cause mortality.Methods: We followed 43 972 Japanese participants aged 40 to 79 years for 12 years. Cox proportional hazards regression analysis was used to estimate hazard ratios (HRs), using the following BMI categories: <18.5 (underweight), 18.5–20.9, 21.0–22.9, 23.0–24.9 (reference), 25.0–27.4, 27.5–29.9, and ≥30.0 kg/m2 (obese). Analyses were stratified by age group: middle-aged (40–64 years) vs elderly (65–79 years).Results: We observed a significantly increased risk of mortality in underweight elderly men: the multivariate HR was 1.26 (0.92–1.73) in middle-aged men and 1.49 (1.26–1.76) in elderly men. In addition, we observed a significantly increased risk of mortality in obese middle-aged men: the multivariate HR was 1.71 (1.17–2.50) in middle-aged men and 1.25 (0.87–1.80) in elderly men. In women, there was an increased risk of mortality irrespective of age group in the underweight: the multivariate HR was 1.46 (0.96–2.22) in middle-aged women and 1.47 (1.19–1.82) in elderly women. There was no excess risk of mortality with age in obese women: the multivariate HR was 1.47 (0.94–2.27) in middle-aged women and 1.26 (0.95–1.68) in elderly women.Conclusions: As compared with the reference category, obesity was associated with a high mortality risk in middle-aged men, whereas underweight, rather than obesity, was associated with a high mortality risk in elderly men. In women, obesity was associated with a high mortality risk during middle age; underweight was associated with a high mortality risk irrespective of age. The mortality risk due to underweight and obesity may be related to sex and age.

• 日本疫学会の論文
• 2010-09-01

著者

• Haketa Akira

  日本大学 医学部内科学系腎臓高血圧内分泌内科

• TSUJI Ichiro

  Division of Epidemiology, Department of Public Health and Forensic Medicine, Graduate School of Medi

• HOZAWA Atsushi

  Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Gradu

• KURIYAMA Shinichi

  Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Gradu

• Hozawa A

  Division Of Epidemiology Department Of Public Health And Forensic Medicine Tohoku University Graduat

• Hozawa Atsushi

  東北大学 医学系研究科運動学分野

• Hozawa Atsushi

  Division Of Epidemiology And Community Health School Of Public Health University Of Minnesota:depart

• Tsuji I

  Division Of Epidemiology Department Of Public Health And Forensic Medicine Tohoku University Graduat

• Tsuji Ichiro

  東北大学 医学系研究科運動学分野

• Kuriyama Shinichi

  東北大学 医学系研究科循環器病態学

• Kuriyama Shinichi

  Division Of Epidemiology Department Of Public Health & Forensic Medicine Tohoku University Gradu

• Ohmori Matsuda

  Division Of Epidemiology Department Of Public Health And Forensic Medicine Tohoku University Graduat

• KAKIZAKI Masako

  Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Gradu

• SONE Toshimasa

  Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Gradu

• NAGAI Masato

  Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Gradu

• SUGAWARA Yumi

  Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Gradu

• Tsuji Ichiro

  東北大学 医学系研究科循環器病態学

• Hara Azusa

  東北大学 臨床薬学

• Kawai Masaaki

  Division Of Surgical Oncology Graduate School Of Medicine Tohoku University

• Kikuchi Masahiko

  Comprehensive Dentistry Tohoku University Hospital

• Sato Yuki

  The Division Of Epidemiology Department Of Public Health And Forensic Medicine Tohoku University Gra

• Nagai Masato

  Division Of Epidemiology Department Of Public Health And Forensic Medicine Tohoku University Graduat

• Sugawara Yumi

  Division Of Epidemiology Department Of Public Health And Forensic Medicine Tohoku University Graduat

• Sone Toshimasa

  Division Of Epidemiology Department Of Public Health And Forensic Medicine Tohoku University Graduat

• Kanemura Seiki

  Division Of Epidemiology Department Of Public Health And Forensic Medicine Tohoku University Graduat

• Hozawa Atsushi

  Department Of Public Health And Forensic Medicine Tohoku University Graduate School Of Medicine And

• Tsuji Ichiro

  Division Of Epidemiology Department Of Public Health And Forensic Medicine Tohoku University Graduat

• Kakizaki Masako

  Division Of Epidemiology Department Of Public Health And Forensic Medicine Tohoku University Graduat

• Kuriyama Shinichi

  東北大学 医学系研究科公衆衛生学

• Ishida Tsunehiro

  Division Of Epidemiology Department Of Public Health And Forensic Medicine Tohoku University Graduat

• Kakizaki Masako

  Division Of Epidemiology Department Of Public Health And Forensic Medicine Tohoku University Graduat

• Kuriyama Shinichi

  Division Of Epidemiology Tohoku University Graduate School Of Medicine

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