4G/5G Variant of Plasminogen Activator Inhibitor-1 Gene and Severe Pregnancy-Induced Hypertension : Subgroup Analyses of Variants of Angiotensinogen and Endothelial Nitric Oxide Synthase
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概要
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Background: Pregnancy-induced hypertension (PIH) is a common cause of perinatal mortality. It is believed to result from the interaction of several factors, including those related to the blood coagulation system. We performed genotyping and subgroup analyses to determine if the 4G/5G genotypes of the plasminogen activator inhibitor-1 gene (PAI-1) play a role in the pathogenesis of PIH, and to evaluate possible interactions of the PAI-1 polymorphisms with those of the angiotensinogen gene (AGT) and the endothelial nitric oxide synthase gene (NOS3).Methods: An association study of PAI-1 polymorphism, and subgroup analyses of common variants of AGT and NOS3, among 128 patients with PIH and 376 healthy pregnant controls.Results: No significant differences were found between the cases and controls in the frequencies of allele 4G or the 4G/4G genotype. In subgroup analyses, after adjustment for multiple comparison, a significant association with the AGT TT genotype was found among women with the PAI-1 4G/4G genotype, and an association with the NOS3 GA+AA genotype was found among women with the 5G/5G or 4G/5G genotypes.Conclusions: Our findings suggest that there are at least 2 pathways in the pathogenesis of severe PIH. However, with respect to early prediction and prevention of severe PIH, although the PAI-1 4G/4G genotype alone was not a risk factor for severe PIH, the fact that PAI-1 genotypes are associated with varying risks for severe PIH suggests that PAI-1 genotyping of pregnant women, in combination with other tests, may be useful in the development of individualized measures that may prevent severe PIH.
- 日本疫学会の論文
- 2009-11-01
著者
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藤本 征一郎
北大産婦人科
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HATA Akira
Department of Public Health, Graduate School of Medicine, Chiba University
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Fujimoto Seiichiro
Tenshi Hospital
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Sakuragi Noriaki
Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine
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Haketa Akira
日本大学 医学部内科学系腎臓高血圧内分泌内科
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Hata Akira
千葉大学 医学研究院公衆衛生学
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山田 秀人
北海道大学産婦人科
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KOBASHI Gen
Hokkaido University Graduate School of Medicine
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Minakami Hisanori
Department Of Obstetrics And Gynecology Hokkaido University School Of Medicine
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Minakami H
Department Of Obstetrics And Gynecology Hokkaido University Graduate School Of Medicine
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YAMADA Hideto
Department of Obstetrics and Gynecology, Hokkaido University School of Medicine
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Hata A
Chiba Univ. Graduate School Of Medicine Chiba Jpn
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Ohta Kaori
Molecular Biostatistics Research Team Research Center For Charged Particle Therapy National Institut
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Kobashi G
Molecular Biostatistics Research Team Research Center For Charged Particle Therapy National Institut
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Kobashi Gen
Department Of Public Health Hokkaido University Graduate School Of Medicine
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Yamada Hideto
Department Of Obstetrics And Gynecology Hokkaido University Graduate School Of Medicine
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Tamashiro Hiko
Department Of Global Health And Epidemiology Hokkaido University Graduate School Of Medicine
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Tamashiro Hiko
Department Of Global Health And Epidemiology Division Of Preventive Medicine Hokkaido University Gra
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Hata Akira
Laboratory For Gastrointestinal Diseases Snp Research Center Riken
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Hata Akira
Department Of Public Health Chiba University Graduate School Of Medicine
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Hata Akira
Department Of Public Health Asahikawa Medical College
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Hata Akira
Division Of Internal Medicine Toyonaka Municipal Hospital
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KOBASHI Gen
Molecular Biostatistics Research Team, Research Center for Charged Particle Therapy, National Instit
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FUJIMOTO Seiichiro
Sapporo Maternity Women's Hospital
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藤本 征一郎
北大医学部産婦人科
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Fujimoto Seiichiro
Sapporo Maternity Women's Hospital
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Fujimoto Seiichiro
Department Of Obstetrics And Gynecology Hokkaido University Graduate School Of Medicine
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Sakuragi Noriaki
Department Of Gynecology Hokkaido University
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Minakami Hisanori
Department Of Gynecology Hokkaido University
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Kobashi Gen
Molecular Biostatistics Research Team Research Center For Charged Particle Therapy National Institut
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Hata A
Laboratory For Gastrointestinal Diseases Snp Research Center Riken
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Hata Akira
Disco Corporation
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Sakuragi Noriaki
Department Of Obstetrics And Gynecology
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Minakami Hisanori
Department Of Obstetrics And Gynecology
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Sakuragi Noriaki
Department Of Gynecology Hokkaido University Graduate School Of Medicine
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Fujimoto Seiichiro
Deparment Of Obstetrics And Gynecology Hokkdaido University School Of Medicine
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Yamada Hideto
Obstetrics And Gynecology Hokkaido University Graduate School Of Medicine
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TAMASHIRO Hiko
Department of Global Health & Epidemiology, Graduate School of Medicine, Hokkaido University
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