Identification and Classification of a Two-Component System Based on Domain Structures in Bacteria and Differences in Domain Structure between Gram-Positive and Gram-Negative Bacteria
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概要
- 論文の詳細を見る
Genome sequencing has revealed many pairs of proteins termed two-component systems (TCSs) in bacteria. Each pair consists of a sensor or histidine kinase (HK) and an effector or response regulator (RR). The HK is usually a membrane-spanning protein that senses specific environmental parameters and communicates this information to the cytoplasmic RR protein through phosphotransfer reactions to cope with a variety of environmental stresses, including osmotic pressure, nitrogen lack, phosphoric acid lack, and the presence of oxygen. Furthermore, some proteins have been identified as hybrid kinases composed of HK and RR. We identified the domain structures of 360 bacteria and 43 archaea by domain search against the PFAM database using HMMER. We then classified 8,573 HK, 10,807 RR, and 2,477 hybrid kinases. In addition, we identified specific domains among phylogenic clusters based on differences in domain structure of TCS genes applying the Signal-to-Noise ratio.
- 社団法人 日本農芸化学会の論文
- 2010-04-23
著者
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KUHARA Satoru
Graduate School of Genetic Resources Technology, Kyushu University
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Kawamura Shunsuke
Department Of Bioscience School Of Agriculture Tokai University
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Kuhara Satoru
Faculty Of Agriculture Kyushu University
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Muta Shigeru
Graduate School of Genetic Resources Technology
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Kuhara S
Department Of Bioscience School Of Agriculture Tokai University
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Muta Shigeru
Graduate School Of Bioresource And Bioenvironmental Sciences Kyushu University
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KIM Sangwan
Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
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HIRAKAWA Hideki
Laboratory for Plant Genome Informatics, Department of Plant Genome Research, Kazusa DNA Research In
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Kuhara Satoru
Graduate School Of Bioresource And Bioenvironmental Sciences Kyushu University
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Hirakawa Hideki
Laboratory For Plant Genome Informatics Department Of Plant Genome Research Kazusa Dna Research Inst
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Kim Sangwan
Graduate School Of Bioresource And Bioenvironmental Sciences Kyushu University
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Kuhara Satoru
Graduate School Of Genetic Resources Technol. Kyushu Univ.
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