Effect of Inducible Expressed Human Cytomegalovirus Immediate Early 86 Protein on Cell Apoptosis
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概要
- 論文の詳細を見る
Human cytomegalovirus is a common human pathogen that can cause life-threatening disease under certain conditions. During infection of host cells, the virus expresses regulatory proteins such as IE72 and IE86 that are important for viral propagation. IE86 plays a critical role in the modulation of viral replication as well as host cell cycle control and apoptosis. In this study, a Tet-On system was used to quantify the effect of IE86 on apoptosis and p53 expression. Our results indicate that IE86 inhibits tumor necrosis factor (TNF)-α induced apoptosis and that the anti-apoptotic activity of this viral protein correlates with its expression levels. In addition, IE86 did not alter the mRNA level of p53. The system developed should provide a method for functional analysis of human cytomegalovirus (HCMV) IE86 protein.
- 社団法人 日本農芸化学会の論文
- 2009-06-23
著者
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Li Ling
Department of Cardiology, the First Affiliated Hospital, Zhengzhou University
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Liu Zhijun
Department Of Chemical Equipment And Control Engineering School Of Chemical Engineering Dalian Unive
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Wang Bin
Department Of Electrical And Electronic Engineering Akita University
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Li Ling
Department Of Microbiology Key Laboratory Of Medicine And Biotechnology Of Qingdao Qingdao Universit
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Wang Haitao
Department Of Microbiology Key Laboratory Of Medicine And Biotechnology Of Qingdao Qingdao Universit
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Wang Bin
Department Of Microbiology Key Laboratory Of Medicine And Biotechnology Of Qingdao Qingdao Universit
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Liu Zhijun
Department Of Microbiology Key Laboratory Of Medicine And Biotechnology Of Qingdao Qingdao Universit
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Song Xuxia
Department Of Microbiology Key Laboratory Of Medicine And Biotechnology Of Qingdao Qingdao Universit
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Yan Zhiyong
Department Of Microbiology Key Laboratory Of Medicine And Biotechnology Of Qingdao Qingdao Universit
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Ding Shouyi
Department Of Microbiology Key Laboratory Of Medicine And Biotechnology Of Qingdao Qingdao Universit
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Bai Zhiqiang
Department Of Microbiology Key Laboratory Of Medicine And Biotechnology Of Qingdao Qingdao Universit
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Qian Dongmeng
Department Of Microbiology Key Laboratory Of Medicine And Biotechnology Of Qingdao Qingdao Universit
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Wang Bin
Department Of Chemistry Marshall University
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Wang Haitao
Department Of Metallurgical Engineering University Of Utah
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