Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Are Involved in Sinoaortic Denervation-Induced Cardiovascular Hypertrophy in Rats
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概要
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The balance of angiotensin-converting enzyme (ACE) and angiotensin-converting enzyme 2 (ACE2) in high blood pressure variability (BPV) induced cardiovascular hypertrophy remains elusive. The aim of the present work was to investigate expression and activity of ACE and ACE2 in the heart and aorta of sinoaortic denervation (SAD) rats with high BPV and normal BP, and explore the potential role of ACE and ACE2 in high BPV-induced cardiovascular damage. Hemodynamics, cardiovascular hypertrophy, angiotensin II (Ang II) concentrations, ACE and ACE2 activity were determined. Cardiac-tissue ACE and ACE2 expression were assayed by real-time polymerase chain reaction and Western blot. Compared with sham-operated rats, systolic BPV and diastolic BPV increased and baroreflex sensitivity decreased significantly in SAD rats. SAD rats presented with obvious cardiovascular hypertrophy characterized by increased ratio of left ventricle weight to body weight and aortic weight to the length of aorta. There was no difference in plasma Ang II concentration between sham-operated and SAD rats. The cardiac and aortic ACE expression, aortic ACE2 expression and ACE activity were elevated in SAD rats. There was no significant difference in cardiac ACE2 expressions between sham-operated and SAD rats. The present work demonstrated that cardiac and aortic ACE expression, aortic ACE2 expression and ACE activity were increased in SAD rats. It is the tissue rather than the circulating renin–angiotensin system that contributes to high BPV-induced cardiovascular hypertrophy.
著者
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Su Ding-feng
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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Zhang Li-chao
Department Of Pharmacy Changhai Hospital Second Military Medical University
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Li Ling
Department of Cardiology, the First Affiliated Hospital, Zhengzhou University
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Wei Xin
Department Of Anesthesiology Anhui Medical University Affiliated Auhui Provincial Hospital
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Li Ling
Department of Pharmacology, Second Military Medical University, China
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Wei Xin
Department of Pharmacology, Second Military Medical University, China
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Su Ding-Feng
Department of Pharmacology, Second Military Medical University, China
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Li Zhen-Zhen
Department of Pharmacology, Second Military Medical University, China
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Wang Zhi-Bin
Department of Pharmacology, Second Military Medical University, China
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Zhang Li-Chao
Department of Pharmacy, Shanghai Seventh People's Hospital
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Yu Yong-Sheng
Department of Pharmacology, Second Military Medical University, China
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