Effects of a Casein Hydrolysate Prepared from Aspergillus oryzae Protease on Adjuvant Arthritis in Rats

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概要

• 論文の詳細を見る

• We evaluated the effects of a casein hydrolysate (CH) prepared from Aspergillus oryzae protease on rat adjuvant arthritis, a model of human rheumatoid arthritis. CH was administered orally once a day to the animals for 22 d after the adjuvant injection. CH suppressed swelling in the adjuvant-uninjected hind paws, and a higher dose of CH suppressed the increase in arthritic score and swelling of the adjuvant-injected hind paws. A histopathological examination revealed evidence that the higher dose of CH suppressed the articular changes in the rats. In addition, CH suppressed the production of nitric oxide and prostaglandin E2 in the plasma of the rats. These results suggest that CH had a suppressive effect on adjuvant arthritis by inhibiting the acute and chronic inflammatory reactions.

• 社団法人 日本農芸化学会の論文
• 2008-08-23

著者

• Yang Xiao-ping

  Environmental Res. Center Mercian Cleantec Corp.

• Hirano Shi-ichi

  Department Of Applied Chemistry Graduate School Of Engineering Nagoya University

• KUBOKI Hiroshi

  Environmental Research Center, Mercian Cleantec Corporation

• Hirano Shin‐ichi

  Division Of Nanomaterials Science Ecotopia Science Institute Nagoya University

• Kuboki Hiroshi

  Environmental Res. Center Mercian Cleantec Corp.

• Kuboki Hiroshi

  Environmental Research Center Mercian Cleantec Corporation

• Hirano S

  Central Research Laboratories Mercian Corp.

• Hirano Shin-ichi

  Environmental Research Center Mercian Cleantec Corporation

• Yang Xiao-ping

  Environmental Research Center Mercian Cleantec Corporation

• Abe Chiyuki

  St. Mariana University School Of Medicine Department Of Medicine Division Of Rheumatology

• HATORI Michio

  R and D Center, Calpis Co., Ltd.

• OHKI Kohji

  R and D Center, Calpis Co., Ltd.

• Hatori Michio

  R And D Center Calpis Co. Ltd.

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