Prevention of Pathogenic Escherichia coli Infection in Mice and Stimulation of Macrophage Activation in Rats by an Oral Administration of Probiotic Lactobacillus casei I-5
スポンサーリンク
概要
- 論文の詳細を見る
Lactobacillus casei I-5 isolated from an alcohol fermentation broth enhanced immunity and prevented pathogenic infection as a probiotic. Mice fed with I-5 cells for 11 days prior to an intraperitoneal challenge with pathogenic Escherichia coli Juhl exhibited a high survival rate compared with the control group. Rats fed with I-5 cells for 10 days significantly increased the phagocytosis of peritoneal macrophages. In a cell culture system employing peritoneal macrophages from rats, the I-5 administration activated NF-κB stimulated by LPS. It also enhanced LPS-stimulated IL-12 and TNF-α production, but not IL-6 production. These results show that L. casei I-5 effectively prevented infection by pathogenic E. coli possibly through the activation of peritoneal macrophages. The strain would be useful to prevent pathogenic microbial infections in humans and farm animals.
- 2007-04-23
著者
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Hirano Shin-ichi
Environmental Science Research Laboratory, Central Research Institute of Electric Power Industry (CR
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Yang Xiao-ping
Environmental Res. Center Mercian Cleantec Corp.
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Hirano Shi-ichi
Department Of Applied Chemistry Graduate School Of Engineering Nagoya University
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Ishida-Fujii Keiko
R & D Center, Japan Alcohol Corporation
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Sato Rieko
R & D Center, Japan Alcohol Corporation
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Goto Shingo
R & D Center, Japan Alcohol Corporation
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KUBOKI Hiroshi
Environmental Research Center, Mercian Cleantec Corporation
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SATO Michikatsu
R & D Center, Japan Alcohol Corporation
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Hirano Shin‐ichi
Division Of Nanomaterials Science Ecotopia Science Institute Nagoya University
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Kuboki Hiroshi
Environmental Res. Center Mercian Cleantec Corp.
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Kuboki Hiroshi
Environmental Research Center Mercian Cleantec Corporation
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Goto Shingo
R & D Center Japan Alcohol Corporation
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Hirano S
Central Research Laboratories Mercian Corp.
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Hirano Shin-ichi
Environmental Research Center Mercian Cleantec Corporation
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Ishida Fujii
R & D Center Japan Alcohol Corporation
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ISHIDA FUJII
R & D Center, Japan Alcohol Corporation
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Yang Xiao-ping
Environmental Research Center Mercian Cleantec Corporation
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Sato Michikatsu
R & D Center Japan Alcohol Corporation
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Sato Rieko
R & D Center Japan Alcohol Corporation
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