Multiple Brain Tumors of Diffuse Large B Cell Lymphoma in a Patient with Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma : PCR and DNA Sequence Analysis Show Evidence of Differences in Clonality of the Two B Cell Malignancies
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概要
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Multiple brain tumors of diffuse large B cell lymphoma (DLBL) were observed in a 75-year-old man with Waldenströms macroglobulinemia (WM). Paravertebral and multiple subcutaneous nodules occurred in succession and he died 4 months after onset. We investigated B cell monoclonality by means of polymerase chain reaction (PCR) analysis and sequencing of the immunoglobulin heavy chain of paraffin-embedded sections. The PCR product of the brain tumors showed a different rearrangement pattern from those of the other sections. The co-occurrence of DLBL with WM is rare, and some investigators have examined the clonality of the two malignancies. This case is important because DLBL brain tumors co-occurred with WM, enabling us to prove that DLBL and WM have different clonality.
- 社団法人 日本内科学会の論文
- 2004-10-01
著者
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HATTORI Takeshi
Department of Applied Physics, Tokyo University of Science
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SUZUKI Takefumi
Department of Ophthalmology, Tohoku University School of Medicine
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ITO Toshiro
Second Department of Internal Medicine, Shinshu University School of Medicine
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Sano Kenji
Department of Laboratory Medicine, Shinshu University Hospital
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MARUYAMA Keiko
Department of Pharmacology, Niigata College of Pharmacy
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Ito Toshiro
Second Department Of Internal Medicine Shinshu University School Of Medicine
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Ito Toshiro
Second Department Of Medicine Shinshu University
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Tojo Kana
Department of Medicine (Neurology), Shinshu University School of Medicine
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Asano Naoko
Second Department Of Medicine Shinshu University
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Sano Kenji
Department Of Laboratory Medicine Shinshu University School Of Medicine
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Maruyama Keiko
Department Of Neurology Suwa Red Cross Hospital
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Tojo Kana
Department Of Neurology Suwa Red Cross Hospital
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Suzuki Takefumi
Department Of Laboratory Medicine Shinshu University
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Hattori Takeshi
Department Of Applied Physics Tokyo University Of Science
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Hattori Takeshi
Department Of Applied Physics Faculty Of Science Science University Of Tokyo:(present)the Institute
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Hattori Takeshi
Department Of Neurology Suwa Red Cross Hospital
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Sano Kenji
Department Of Laboratory Medicine School Of Medicine Shinshu University
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Sano Kenji
Department Of Laboratory Medicine Shinshu University
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Sano Kenji
Department Of Applied Chemistry Faculty Of Engineering Toyama University
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Maruyama Keiko
Department Of Clinical Laboratory Science Kanazawa University Graduate School Kanazawa University
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Tojo Kana
Department of Medicine (Neurology & Rheumatology), Shinshu University School of Medicine, Japan
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