Richter Transformation in the Brain from Chronic Lymphocytic Leukemia
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概要
- 論文の詳細を見る
Richter syndrome (RS) involves the development of an aggressive lymphoma in patients with chronic lymphocytic leukemia (CLL). Diffuse large B-cell lymphoma (DLBCL) is the most common type of RS. Extranodal RS occasionally occurs ; however, isolated lesions in the central nervous system (CNS) of RS are rarely seen and the features have not been well described. We describe a Japanese patient who developed isolated involvements of the parenchyma of the CNS as a manifestation of RS two years after the initial diagnosis of CLL. DLBCL in the cerebrum was confirmed to be clonally related to the CLL cells by <I>immunoglobulin heavy chain (IGH)</I> gene analysis, utilizing the identical VH-D-J regions with additional mutations in the IGH variable region. [<I>J Clin Exp Hematop 53(2) : 157-160, 2013</I>]
著者
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Ito Toshiro
Division I Of Gene Expression And Regulation National Institute For Basic Biology:department Of Biop
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Ishida Fumihiro
Department Of Internal Medicine Shinshu University School Of Medicine
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Asano Naoko
Department Of Anesthesiology Iwate Medical University School Of Medicine
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Sano Kenji
Department Of Applied Chemistry Faculty Of Engineering Toyama University
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Sakai Hitoshi
Division of Hematology, Department of Internal Medicine, Shinshu University School of Medicine
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Nakazawa Hideyuki
Division of Hematology, Department of Internal Medicine, Shinshu University School of Medicine
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Takezawa Yuka
Central Laboratory Department, Shinshu University Hospital
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Matsuda Kazuyuki
Central Laboratory Department, Shinshu University Hospital
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Ishida Fumihiro
Department of Biomedical Laboratory Sciences, Shinshu University School of Medicine
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