Peripheral T-cell Lymphoma Following Diffuse Large B-cell Lymphoma Associated with Celiac Disease
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概要
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Celiac disease is a risk factor for lymphoma. Previously, we reported a case of diffuse large B-cell lymphoma (DLBCL) associated with celiac disease in a Japanese patient. Without any signs of DLBCL recurrence, he suddenly developed gastrointestinal symptoms and subcutaneous masses after resuming a gluten-containing diet. Peripheral T-cell lymphoma (PTCL) was diagnosed. Although a complete response was seen for 8 months, he was later admitted again with pleural and pericardial effusion due to PTCL. Expression of cytotoxic molecules, CCR4 and CXCR4 were all confirmed in PTCL cells, and the patient died soon afterwards. Clinically speaking, even though no gastrointestinal symptoms were seen, a gluten-free diet should have been strongly recommended for this patient.
著者
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Ishida Fumihiro
Department Of Internal Medicine Shinshu University School Of Medicine
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Asano Naoko
Department Of Anesthesiology Iwate Medical University School Of Medicine
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Komiyama Yuichi
Department Of Medicine Gastroenterology Shinshu University School Of Medicine
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NAKAMURA Shigeo
Department of Applied Chemistry, Faculty of Engineering, Kanagawa University
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Makishima Hideki
Department of Internal Medicine, Division of Hematology, Shinshu University School of Medicine
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Momose Kayoko
Department of Internal Medicine, Division of Hematology, Shinshu University School of Medicine
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Asano Naoko
Department of Pathology and Clinical Laboratories, Nagoya University School of Medicine
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Ishida Fumihiro
Department of Biomedical Laboratory Sciences, Shinshu University School of Medicine
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Nakamura Shigeo
Department of Pathology and Clinical Laboratories, Nagoya University School of Medicine
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